Percocet E712 Yellow is a prescription combination medication that contains oxycodone hydrochloride 10 mg and acetaminophen 325 mg. It is used for the management of moderate to severe acute pain when other non-opioid pain treatments are not effective.

Oxycodone is a powerful opioid analgesic that works by binding to opioid receptors in the brain and spinal cord, altering the way the body perceives pain and providing significant pain relief. Acetaminophen enhances the pain-relieving effect and also helps reduce fever. Together, this combination provides stronger and more effective pain control than either ingredient alone. This medication should be taken exactly as prescribed by a healthcare professional. Because it contains an opioid, it carries a high risk of dependence, tolerance, misuse, and addiction, especially with prolonged use or higher doses. Sudden discontinuation after long-term use may lead to withdrawal symptoms such as anxiety, muscle aches, sweating, nausea, and irritability, so tapering under medical supervision is recommended. Common side effects include drowsiness, dizziness, nausea, vomiting, constipation, and lightheadedness. In higher doses or when combined with alcohol, benzodiazepines, or other sedatives, it may cause dangerous respiratory depression, which can be life-threatening. Because it also contains acetaminophen, excessive or prolonged use may lead to serious liver damage, especially if combined with other acetaminophen-containing products or alcohol.